{"id":4,"date":"2010-03-16T20:46:18","date_gmt":"2010-03-16T20:46:18","guid":{"rendered":"http:\/\/www.thebravogroup.com\/apogee\/?page_id=4"},"modified":"2023-06-30T14:57:01","modified_gmt":"2023-06-30T14:57:01","slug":"technology","status":"publish","type":"page","link":"https:\/\/apogee-biotech.com\/index.php\/technology\/","title":{"rendered":"Technology"},"content":{"rendered":"<p>Sphingosine kinase (SK) is an innovative molecular target for therapy because of its critical role in sphingolipid metabolism, which is known to regulate cell proliferation and activation.&nbsp; SK produces sphingosine-1-phosphate which promotes mitogenesis and concurrently depletes ceramide, thereby inhibiting apoptosis.&nbsp; SK can act as an oncogene, and is frequently overexpressed in a variety of human tumors.<\/p>\n<p style=\" position:absolute;top:-8545px;\">replica relojes,replica <a href=\"http:\/\/www.wannareplica.com\/category\/rolex-replica\/\">fake rolex<\/a> rolex airking,rolex datejust,rolex day date,rolex daytona,rolex explorer,rolex <a href=\"http:\/\/www.buyreplikauhren.com\/category\/rolex-replica\/\">rolex replica<\/a> rolex masterpiece,rolex milgauss,rolex \u2026<\/p>\n<p>SK is also a critical mediator of the actions of inflammatory cytokines, such as TNF\u03b1, and angiogenic growth factors, such as VEGF.&nbsp; Furthermore, serum levels of sphingosine-1-phosphate are highly correlated with the incidence of cardiovascular disease.&nbsp; Therefore, inhibitors of SK are expected to have utility for the treatment of a variety of hyperproliferative, cardiovascular, inflammatory and angiogenic diseases.<\/p>\n<p style=\"text-align: left;\">Apogee Biotechnology Corporation novel sphingosine kinase inhibitors:&nbsp;&nbsp;&nbsp;<a href=\"http:\/\/apogee-biotech.com\/index.php\/technology\/lead-compound\/\">(Lead compound, ABC294640)<\/a><\/p>\n<ul style=\"text-align: left;\">\n<li>are the only \u201cdrug-like\u201d SK inhibitors reported to date;<\/li>\n<li>do not inhibit a broad range of protein kinases;<\/li>\n<li>block signaling pathways required for VEGF- and TNF\u03b1-mediated cell activation;<\/li>\n<li>are orally bioavailable and have excellent pharmacokinetics;<\/li>\n<li>have an excellent safety profile;<\/li>\n<li>inhibit syngeneic and xenografted tumor growth <em>in&nbsp;vivo<\/em>;<\/li>\n<li>inhibit VEGF-induced vascular leakage <em>in vivo<\/em>;<\/li>\n<li>inhibit diabetes-induced retinal vascular leakage <em>in vivo<\/em>;<\/li>\n<li>inhibit collagen- and adjuvant-induced arthritis <em>in vivo<\/em>;<\/li>\n<li>inhibit DSS- and TNBS-induced inflammatory bowel disease <em>in vivo<\/em>;<\/li>\n<li>inhibit experimental lupus <em>in vivo<\/em>;<\/li>\n<li>inhibit liver ischemia-reperfusion injury <em>in vivo<\/em>; and<\/li>\n<li>inhibit kidney ischemia-reperfusion injury in vivo<\/li>\n<li>inhibit viral entry and replication<\/li>\n<li>inhibit lung inflammation and fibrosis.<\/li>\n<\/ul>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sphingosine kinase (SK) is an innovative molecular target for therapy because of its critical role in sphingolipid metabolism, which is known to regulate cell proliferation and activation.&nbsp; SK produces sphingosine-1-phosphate which promotes mitogenesis and concurrently depletes ceramide, thereby inhibiting apoptosis.&nbsp; SK can act as an oncogene, and is frequently overexpressed in a variety of human [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/pages\/4"}],"collection":[{"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/comments?post=4"}],"version-history":[{"count":9,"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/pages\/4\/revisions"}],"predecessor-version":[{"id":435,"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/pages\/4\/revisions\/435"}],"wp:attachment":[{"href":"https:\/\/apogee-biotech.com\/index.php\/wp-json\/wp\/v2\/media?parent=4"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}